A randomized, placebo-controlled, double blind trial. Health effects of vegan diets. Specifically, they cautioned that success observed in the Linxian General Population and Dysplasia trials in reducing risk of cancer 36 may have reflected a borderline-deficient population in China. In food, however, the biological constituents are coordinated. Even compounds generally recognized as safe GRAS can have problems at high doses: for example, vitamin C intake at several grams can result in gastrointestinal effects, such as osmotic diarrhea. Naturally occurring trans fats, such as conjugated linoleic acids found in dairy products, are reflective of ruminant biology and may have beneficial health effects in humans 39 whereas trans fats introduced in food processing have different origins and contexts. Hydroxycinnamic acids found in coffee provide an example of survival of small compounds. Constituents delivered by foods taken directly from their biological environment may have different effects from those formulated through technologic processing, but either way health benefits are likely to be determined by the total diet. A central tenet in this argument is the concept of food synergy 1, 2, 8, a perspective that more information can be obtained by looking at foods rather than at single food components.
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