Consuming a high-fat, high-sugar diet causes a harmful accumulation of fat in the liver that may not reverse even after switching to a healthier diet, according to a new study by scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center. For the study, published Oct. They used the sensor to assess the effects of a high-fat, high-sugar diet on the livers of mice. They then evaluated the outcomes when the mice returned to a healthy diet. Unexpectedly, the researchers found that, while the fat accumulation decreases after returning to a healthy diet, some residual fat remains in certain liver cells long afterwards. Nonalcoholic fatty liver disease NAFLD affects up to 30 percent of people in the United States, where a high-fat, high-sugar diet is common. The condition can progress to a more serious disease involving inflammation, scarring and even liver cancer called nonalcoholic steatohepatitis, or NASH. People who accumulate fat inside liver cells called Kupffer cells, specifically a part of these cells named lysosomes that act like cellular garbage collectors, appear more likely to progress to serious liver disease. Simulated image of the nanoreporter bound to molecules of cholesterol yellow-green. From Galassi et al. Reprinted with permission from AAAS.
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